Publications

Selected publications


Peritonitis

Selgas R et al. ”Immunomodulation of peritoneal macrophages by granulocyte-macrophage colony-stimulating factor in humans.”

Kidney Int 50:2070-2078.

Orozco H et al.  ”Molgramostim (GM-CSF) associated with antibiotic treatment in nontraumatic abdominal sepsis: a randomized, double-blind, placebo-controlled clinical trial.”

Arch Surg 141:150-153. 

Heling af kroniske sår

Hu X et al. ”Topically applied rhGM-CSF for the wound healing: a systematic review.”

Burns 37:729-741. 

Groves RW et al. ”Recombinant human GM-CSF in the treatment of poorly healing wounds.”

Adv Skin Wound Care 13:107-112.

Da Costa RM et al. ”Randomized, double-blind, placebo-controlled, dose-ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers.”

 Wound Repair Regen 7:17-25.

Ghazi K et al. ”Hyaluronan fragments improve wound healing on in vitro cutaneous model through P2X7 purinoreceptor basal activation: role of molecular weight.”

PLoS One 7(11):e48351. 

Humbert P et al. ”Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial.”

Int Wound J 10:159-166.

Tumino G et al. ”Topical treatment of chronic venous ulcers with sucralfate: a placebo controlled randomized study.”

 Int J Mol Med 22:17-23.

Masuelli L et al. ”Topical use of sucralfate in epithelial wound healing: clinical evidences and molecular mechanisms of action.”

Recent Pat Inflamm Allergy Drug Discov 4:25-36.

Kolorektalcancer

Chen Y et al. ”Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade.”

Oncotarget 8:31802-31814. 

Falagas ME et al. ”Fosfomycin.”

Clin Microbiol Rev 29:321-347.  

Kostic AD et al. ”Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.”

Cell Host Microbe 14:207-215. 

Nakatsu G et al. ”Gut mucosal microbiome across stages of colorectal carcinogenesis.”

Nature Commun 6:8727.

Raskov H et al. ”Review: Linking gut microbiota to colorectal cancer.”

J Cancer 8:3378-3395.

Rubinstein MR et al. ”Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.”

Cell Host Microbe 14:195-206.

Sears CL et al. ”Microbes, microbiota, and colon cancer.”

Cell Host Microbe 15:317-328.

Yang Y et al. ”Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating Toll-like receptor 4 signaling to nuclear factor-κB, and up-regulating expression of microRNA-21.”

Gastroenterology 152:851-866.  

Crohns Sygdom

Bernasconi E et al. ”Critical role of the GM-CSF signaling pathway in macrophage pro-repair activities.”

Pathobiology 81:183-189

Bernasconi E et al. ”Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing.”

Inflamm Bowel Dis 16:428-441.

Däbritz J. ”Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn’s disease.”

Am J Physiol Gastrointest Liver Physiol 306:G455-G465.

Däbritz J et al. ”Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease.”

Am J Gastroenterol 108:1901-1910.  

Dogan B et al. ”Multidrug resistance is common in Escherichia coli associated with ileal Crohn’s disease.”

Inflamm Bowel Dis 19:141-150. Egea L et al. ”GM-CSF: a role in immune and inflammatory reactions in the intestine.”

Expert Rev Gastroenterol Hepatol 4:723-731

Egea L et al. ”GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa.”

J Immunol 190:1702-1713

Nylund CM et al. ”Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease.”

J Pediatr Gastroenterol Nutr 52:542-548