The local administration of drugs
The advantages of local administration of drugs for treating diseases that are essentially limited to a
discrete part of the body are:
1. Direct delivery to the site of drug action
This means that less drug has to be used and high local concentrations can be achieved to obtain a
powerful therapeutic effect.
2. Avoiding systemic side effects
The principal repositioned drug in Reponex’s pipeline is the recombinantly produced human biological GM- CSF, a protein molecule which is very much larger than the “small molecule” drugs of traditional pharmaceutics. When delivered directly to its site of action in the organ concerned, it does not readily pass
into blood stream. This protects the patients from the adverse effects that it might have when given systemically, e.g. by intravenous infusion or subcutaneous injection.